ipsecurity for binding instead of location

I have a site in IIS 7.5 that uses multiple bindings to display content on separate domains.

I want to be able to use ipsecurity to restrict access to one of these domains/bindings.

Normally, I could use the location element and path attribute in web.config, however the path attribute takes path info only and not domain info. If it could handle regex that would also work my understanding is that it can’t.

Is what I’m trying to do possible with IIS ipsecurity or will I need a different approach?